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Tuesday, October 11, 2005

Metformin in early pregnancy

I found out I was pregnant on Sept 25th. Today I went in for my first ultrasound thinking i was 7w4d but I was only 6w1d by what the ultrasound measured. The heart beat was 124.

I was put on metformin 500mg once a day to even out my insulin levels b/c of being dx with PCOS and now the doctor wants me to stop it. I read nothing but bad stuff on when you
stop taking that med in the first trimester. I requested to stay on it till I hit my 12 week mark. Is there really any harm on staying on that since I'm only taking that once a day?

Also with the heart beat what is the normal range? Do boys have a faster heartrate or is it girls?


Dear Stephanie,

In one study metformin was shown to dramatically lower the risk of miscarriage in women with PCOS. However, this was a small study and it is difficult to know if the results would be the same when studied in a larger group. There is currently no evidence that metformin causes birth defects, but until recently it was never used in pregnancy so we don't have much experience to go on yet.

Metformin has not been approved or recommended for use in early pregnancy, so it puts most doctors in a difficult situation. The preliminary evidence suggests that it can prevent miscarriage, but it is important to understand that this is an "off-label" (unapproved) use of the drug. As long as you understand the potential risks, your doctor may be willing to let you continue the medication.

As far as the heart rate is concerned: the normal heart rate ranges from 120-160. There is no difference between boys and girls; that's just an old wives tale.



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